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Immunohistochemistry with antibodies against the prion protein combined with special tissue pretreatment regimens gives reliable diagnostic results and,for its applicability to formalin-fixed and paraffin-embedded tissue,is superior to other techniques that may be more sensitive but require fresh,unfixed brain tissue.Our experience suggests the following regimen for the diagnosis of suspected Creutzfeldt-Jakob disease;light microscopy of various brain regions,which in typical cases may lead to definite diagnosis.Immunohistochemistry with antibodies against the prion protein is preferable in all suspected cases of Creutzfeldt-Jakob disease and is mandatory whenever a routine histologic workup does not yield definite results.Additional special techniques can be applied if required. |
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